Dosimetry in Clinical Radiopharmaceutical Therapy of Cancer: Practicality Versus Perfection in Current Practice

Neeta Pandit-Taskar, Amir Iravani, Dan Lee, Heather Jacene, Dan Pryma, Thomas Hope, Babak Saboury, Jacek Capala, Richard L. Wahl

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The use of radiopharmaceutical therapies (RPTs) in the treatment of cancers is growing rapidly, with more agents becoming available for clinical use in last few years and many new RPTs being in development. Dosimetry assessment is critical for personalized RPT, insofar as administered activity should be assessed and optimized in order to maximize tumor-absorbed dose while keeping normal organs within defined safe dosages. However, many current clinical RPTs do not require patient-specific dosimetry based on current Food and Drug Administration-labeled approvals, and overall, dosimetry for RPT in clinical practice and trials is highly varied and underutilized. Several factors impede rigorous use of dosimetry, as compared with the more convenient and less resource-intensive practice of empiric dosing. We review various approaches to applying dosimetry for the assessment of activity in RPT and key clinical trials, the extent of dosimetry use, the relative pros and cons of dosimetry-based versus fixed activity, and practical limiting factors pertaining to current clinical practice.

Original languageEnglish
Pages (from-to)60S-72S
JournalJournal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume62
DOIs
StatePublished - Dec 1 2021

Keywords

  • RPT
  • dosimetry
  • radionuclide
  • radiopharmaceutical therapy
  • theranostics

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