TY - JOUR
T1 - Dosimetric Predictors of Cardiotoxicity in Thoracic Radiotherapy for Lung Cancer
AU - Borkenhagen, Jenna F.
AU - Bergom, Carmen
AU - Rapp, Cooper T.
AU - Klawikowski, Slade J.
AU - Rein, Lisa E.
AU - Gore, Elizabeth M.
N1 - Funding Information:
Dr Bergom reports grants from Susan G. Komen Foundation (CCR17483233), grants from Mary Kay Foundation, grants from American Cancer Society Institutional Review Grant 86-004-26, grants from National Center for Advancing Translational Sciences and the Office of the Director of the National Institutes of Health, grant 8KL2TR000056, grants from Michael H. Keelan, Jr, MD, Research Foundation, and the Cardiovascular Center at the Medical College of Wisconsin, grants from Medical College of Wisconsin Cancer Center, during the conduct of the study. The remaining authors have stated that they have no conflicts of interest.
Funding Information:
Dr Bergom reports grants from Susan G. Komen Foundation ( CCR17483233 ), grants from Mary Kay Foundation , grants from American Cancer Society Institutional Review Grant 86-004-26 , grants from National Center for Advancing Translational Sciences and the Office of the Director of the National Institutes of Health , grant 8KL2TR000056 , grants from Michael H. Keelan, Jr, MD, Research Foundation , and the Cardiovascular Center at the Medical College of Wisconsin , grants from Medical College of Wisconsin Cancer Center, during the conduct of the study. The remaining authors have stated that they have no conflicts of interest.
Publisher Copyright:
© 2019
PY - 2019/11
Y1 - 2019/11
N2 - When treating lung cancer with radiotherapy, higher cardiac doses are associated with worse overall survival, although the association with early cardiotoxicity is poorly understood. In this institutional retrospective review, the volume of ventricles receiving ≥45 Gy radiotherapy dose was associated with early cardiotoxicity. In practice, early cardiotoxicity is under-reported, supporting the need for detailed cardiac evaluations in high-risk patients.
AB - When treating lung cancer with radiotherapy, higher cardiac doses are associated with worse overall survival, although the association with early cardiotoxicity is poorly understood. In this institutional retrospective review, the volume of ventricles receiving ≥45 Gy radiotherapy dose was associated with early cardiotoxicity. In practice, early cardiotoxicity is under-reported, supporting the need for detailed cardiac evaluations in high-risk patients.
KW - Cardiac risk factor
KW - Cardiac substructures
KW - Cardio-oncology
KW - Dose-volume constraint
KW - Overall survival
UR - http://www.scopus.com/inward/record.url?scp=85068540623&partnerID=8YFLogxK
U2 - 10.1016/j.cllc.2019.05.014
DO - 10.1016/j.cllc.2019.05.014
M3 - Article
C2 - 31303452
AN - SCOPUS:85068540623
SN - 1525-7304
VL - 20
SP - 435
EP - 441
JO - Clinical Lung Cancer
JF - Clinical Lung Cancer
IS - 6
ER -