Dosimetric Predictors of Cardiotoxicity in Thoracic Radiotherapy for Lung Cancer

Jenna F. Borkenhagen, Carmen Bergom, Cooper T. Rapp, Slade J. Klawikowski, Lisa E. Rein, Elizabeth M. Gore

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


When treating lung cancer with radiotherapy, higher cardiac doses are associated with worse overall survival, although the association with early cardiotoxicity is poorly understood. In this institutional retrospective review, the volume of ventricles receiving ≥45 Gy radiotherapy dose was associated with early cardiotoxicity. In practice, early cardiotoxicity is under-reported, supporting the need for detailed cardiac evaluations in high-risk patients.

Original languageEnglish
Pages (from-to)435-441
Number of pages7
JournalClinical Lung Cancer
Issue number6
StatePublished - Nov 2019


  • Cardiac risk factor
  • Cardiac substructures
  • Cardio-oncology
  • Dose-volume constraint
  • Overall survival


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