Dosimetric consequences of uncorrected setup errors in helical Tomotherapy treatments of breast-cancer patients

S. Murty Goddu, Sridhar Yaddanapudi, Olga L. Pechenaya, Summer R. Chaudhari, Eric E. Klein, Divya Khullar, Issam El Naqa, Sasa Mutic, Sasha Wahab, Lakshmi Santanam, Imran Zoberi, Daniel A. Low

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Background and purpose: The Tomotherapy Hi-Art II system allows acquisition of pre-treatment MVCT images to correct patient position. This work evaluates the dosimetric impact of uncorrected setup errors in breast-cancer radiation therapy. Materials and methods: Breast-cancer patient-positioning errors were simulated by shifting the patient computed-tomography (CT) dataset relative to the planned photon fluence and re-computing the dose distributions. To properly evaluate the superficial region, film measurements were compared against the Tomotherapy treatment planning system (TPS) calculations. A simulation of the integrated dose distribution was performed to evaluate the setup error impact over the course of treatment. Results: Significant dose differences were observed for 11-mm shifts in the anterolateral and 3-mm shifts in the posteromedial directions. The results of film measurements in the superficial region showed that the TPS overestimated the dose by 14% at a 1-mm depth, improving to 3% at depths ≥5 mm. Significant dose reductions in PTV were observed in the dose distributions simulated over the course of treatment. Conclusions: Tomotherapy's rotational delivery provides sufficient photon fluence extending beyond the skin surface to allow an up to 7-mm uncorrected setup error in the anterolateral direction. However, the steep dose falloff that conforms to the lung surface leads to compromised dose distributions with uncorrected posteromedial shifts. Therefore, daily image guidance and consequent patient repositioning is warranted for breast-cancer patients.

Original languageEnglish
Pages (from-to)64-70
Number of pages7
JournalRadiotherapy and Oncology
Issue number1
StatePublished - Oct 2009


  • Breast cancer
  • Dosimetric consequence
  • Helical Tomotherapy
  • IMRT
  • Setup errors
  • Superficial dose


Dive into the research topics of 'Dosimetric consequences of uncorrected setup errors in helical Tomotherapy treatments of breast-cancer patients'. Together they form a unique fingerprint.

Cite this