TY - JOUR
T1 - Dorsal striatal response to taste is modified by obesity and insulin resistance
AU - Dunn, Julia
AU - Lamichhane, Bidhan
AU - Smith, Gordon
AU - Garner, Amy
AU - Wallendorf, Michael
AU - Hershey, Tamara
AU - Klein, Samuel
N1 - Funding Information:
This study was supported by Veterans Affairs (VA) Career Development Award (1IK2CX000943) to Julia P. Dunn, NIH grants DK56341 (NIH Nutrition and Obesity Research Center), DK20579 (Diabetes Research Center), UL1TR002345 (NIH Clinical and Translational Science Award), and REDCap database grant (UL1 TR000445), the Foundation for Barnes‐Jewish Hospital, and the Centene Corporation contract (P19‐00559) for the Washington University‐Centene ARCH Personalized Medicine Initiative.
Funding Information:
The authors thank Stephens Giddings, PhD, MD, for supervisory and operational guidance, Richard Nagel, Jennifer Shew, and Frieda Custodio for technical assistance, the staff of the Washington University in St. Louis Clinical and Translational Research Unit and Center for Clinical Imaging Research and the VA St. Louis Health Care System Clinical Trials Unit and the participants for their commitment.
Publisher Copyright:
© 2023 The Obesity Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
PY - 2023/8
Y1 - 2023/8
N2 - Objective: In preclinical models, insulin resistance in the dorsal striatum (DS) contributes to overeating. Although human studies support the concept of central insulin resistance, they have not investigated its effect on consummatory reward-induced brain activity. Methods: Taste-induced activation was assessed in the caudate and putamen of the DS with blood oxygen level-dependent (BOLD) functional magnetic resonance imaging. Three phenotypically distinct groups were studied: metabolically healthy lean, metabolically healthy obesity, and metabolically unhealthy obesity (MUO; presumed to have central insulin resistance). Participants with MUO also completed a weight loss intervention followed by a second functional magnetic resonance imaging session. Results: The three groups were significantly different at baseline consistent with the design. The metabolically healthy lean group had a primarily positive BOLD response, the MUO group had a primarily negative BOLD response, and the metabolically healthy obesity group had a response in between the two other groups. Food craving was predicted by taste-induced activation. After weight loss in the MUO group, taste-induced activation increased in the DS. Conclusions: These data support the hypothesis that insulin resistance and obesity contribute to aberrant responses to taste in the DS, which is only partially attenuated by weight loss. Aberrant responses to food exposure may be a barrier to weight loss.
AB - Objective: In preclinical models, insulin resistance in the dorsal striatum (DS) contributes to overeating. Although human studies support the concept of central insulin resistance, they have not investigated its effect on consummatory reward-induced brain activity. Methods: Taste-induced activation was assessed in the caudate and putamen of the DS with blood oxygen level-dependent (BOLD) functional magnetic resonance imaging. Three phenotypically distinct groups were studied: metabolically healthy lean, metabolically healthy obesity, and metabolically unhealthy obesity (MUO; presumed to have central insulin resistance). Participants with MUO also completed a weight loss intervention followed by a second functional magnetic resonance imaging session. Results: The three groups were significantly different at baseline consistent with the design. The metabolically healthy lean group had a primarily positive BOLD response, the MUO group had a primarily negative BOLD response, and the metabolically healthy obesity group had a response in between the two other groups. Food craving was predicted by taste-induced activation. After weight loss in the MUO group, taste-induced activation increased in the DS. Conclusions: These data support the hypothesis that insulin resistance and obesity contribute to aberrant responses to taste in the DS, which is only partially attenuated by weight loss. Aberrant responses to food exposure may be a barrier to weight loss.
UR - http://www.scopus.com/inward/record.url?scp=85165462749&partnerID=8YFLogxK
U2 - 10.1002/oby.23799
DO - 10.1002/oby.23799
M3 - Article
C2 - 37475685
AN - SCOPUS:85165462749
SN - 1930-7381
VL - 31
SP - 2065
EP - 2075
JO - Obesity
JF - Obesity
IS - 8
ER -