Doppler tissue imaging in children following cardiac transplantation: A comparison to catheter derived hemodynamics

David J. Goldberg, Michael D. Quartermain, Andrew C. Glatz, E. Kevin Hall, Erin Davis, Stephanie A. Kren, Brian D. Hanna, Meryl S. Cohen

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Previous studies have demonstrated a correlation between E:E a and ventricular filling pressure in adults after heart transplantation. We sought to determine if E:E a correlates with filling pressure after heart transplantation in children. A prospective analysis of children who have undergone heart transplantation was performed. Inflow and myocardial velocities were recorded and compared to catheter-derived filling pressures and rejection status. We performed 61 studies in 49 subjects. No correlation was found between septal E:E a and PCWP (r = 0.14, p = 0.28); or between lateral tricuspid E:E a and mean RAp (r = 0.04, p = 0.79). However, the mean PCWP was higher among subjects with elevated septal E:E a (>12) compared to normal E:E a (12.3 ± 2.8 mmHg vs. 10.1 ± 2.9 mmHg, p = 0.02). Similarly, mean RAp was higher among subjects with an elevated lateral tricuspid E:E a (>10) compared to normal lateral tricuspid E:E a (7.7 ± 2.1 mmHg vs. 6.0 ± 2.4 mmHg, p = 0.04). Elevated septal E:E a was also associated with high-grade cellular rejection (OR = 17.3 [95% CI 1.4-221], p = 0.028). In children following heart transplant, E:E a does not correlate well with the range of filling pressures seen after pediatric heart transplantation. However, a septal E:E a > 12 is associated with elevated PCWP and high grade cellular rejection and a lateral tricuspid E:E a > 10 is associated with elevated mean RAp.

Original languageEnglish
Pages (from-to)488-494
Number of pages7
JournalPediatric transplantation
Issue number5
StatePublished - Aug 2011


  • echocardiography
  • pediatric heart transplant


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