Donor-derived cell free DNA as a biomarker in kidney transplantation

Tarek Abdulhadi, Louai Alrata, Casey Dubrawka, Gwendolyn Amurao, Sri Mahathi Kalipatnapu, Che Isaac, Shelden Rodrigues, Karen Marie Flores, Dema Yaseen Alsabbagh, Omar Alomar, Tarek Alhamad

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The early detection of acute rejection in the allograft is important as it provides an opportunity for timely therapeutic intervention in order to preserve graft function and achieve longer graft survival. Donor-derived cell-free DNA (dd-cfDNA) has emerged as a new biomarker in the field of kidney transplantation. In this review, we used data from various studies to examine the role of dd-cfDNA in comparison to creatinine and donor-specific antibodies in the early detection of transplant rejection. We also reviewed the use of dd-cfDNA in other organ transplants as well as the challenges and potential future direction for dd-cfDNA as a diagnostic tool.

Original languageEnglish
Pages (from-to)771-780
Number of pages10
JournalPharmacogenomics
Volume24
Issue number14
DOIs
StatePublished - Sep 1 2023

Keywords

  • biomarker
  • cell-free DNA
  • cfDNA
  • ddcfDNA
  • donor derived cell-free DNA
  • kidney
  • rejection
  • transplant

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