Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis

Grant A. Challen

doi:10.1016/j.stem.2016.12.008

Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis

Grant A. Challen

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

Somatic mutations in DNMT3A are one of the most prevalent genetic abnormalities found in acute myeloid leukemia (AML) patients. A new study by Guryanova et al. sheds mechanistic insight into how the most common DNMT3A variant protein contributes to AML using a combination of mouse genetics and primary patient samples.

Original language	English
Pages (from-to)	7-8
Number of pages	2
Journal	Cell Stem Cell
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.stem.2016.12.008
State	Published - Jan 5 2017

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title = "Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis",

abstract = "Somatic mutations in DNMT3A are one of the most prevalent genetic abnormalities found in acute myeloid leukemia (AML) patients. A new study by Guryanova et al. sheds mechanistic insight into how the most common DNMT3A variant protein contributes to AML using a combination of mouse genetics and primary patient samples.",

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AB - Somatic mutations in DNMT3A are one of the most prevalent genetic abnormalities found in acute myeloid leukemia (AML) patients. A new study by Guryanova et al. sheds mechanistic insight into how the most common DNMT3A variant protein contributes to AML using a combination of mouse genetics and primary patient samples.

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Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis

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