Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

Carrie L. Lucas, Hye Sun Kuehn, Fang Zhao, Julie E. Niemela, Elissa K. Deenick, Umaimainthan Palendira, Danielle T. Avery, Leen Moens, Jennifer L. Cannons, Matthew Biancalana, Jennifer Stoddard, Weiming Ouyang, David M. Frucht, V. Koneti Rao, T. Prescott Atkinson, Anahita Agharahimi, Ashleigh A. Hussey, Les R. Folio, Kenneth N. Olivier, Thomas A. FleisherStefania Pittaluga, Steven M. Holland, Jeffrey I. Cohen, Joao B. Oliveira, Stuart G. Tangye, Pamela L. Schwartzberg, Michael J. Lenardo, Gulbu Uzel

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Medicine and Dentistry

Biochemistry, Genetics and Molecular Biology

Immunology and Microbiology