Does my mouse have Alzheimer's disease?

J. C. Dodart, C. Mathis, K. R. Bales, S. M. Paul

Research output: Contribution to journalReview article

114 Scopus citations

Abstract

Small animal models that manifest many of the characteristic neuropathological and behavioral features of Alzheimer's disease (AD) have been developed and have proven of great value for studying the pathogenesis of this disorder at the molecular, cellular and behavioral levels. The great progress made in our understanding of the genetic factors that either cause or contribute to the risk of developing AD has prompted many laboratories to create transgenic (tg) mice that overexpress specific genes which cause familial forms of the disease. Several of these tg mice display neuropathololgical and behavioral features of AD including amyloid β-peptide (Aβ) and amyloid deposits, neuritic plaques, gliosis, synaptic alterations and signs of neurodegeneration as well as memory impairment. Despite these similarities, important differences in neuropathology and behavior between these tg mouse models and AD have also been observed, and to date no perfect animal model has emerged. Moreover, ascertaining which elements of the neuropathological and behavioral phenotype of these various strains of tg mice are relevant to that observed in AD continues to be a challenge. Here we provide a critical review of the AD-like neuropathology and behavioral phenotypes of several well-known and utilized tg mice that express human APP transgenes.

Original languageEnglish
Pages (from-to)142-155
Number of pages14
JournalGenes, Brain and Behavior
Volume1
Issue number3
DOIs
StatePublished - Aug 1 2002
Externally publishedYes

Keywords

  • APP
  • Alzheimer's disease
  • Amyloid
  • Behavior
  • Learning and memory
  • Neuropathology
  • Transgenic mouse models

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