TY - JOUR
T1 - Do PPARs play a role in cardiac hypertrophy and heart failure?
AU - Tian, Qi
AU - Barger, Philip M.
PY - 2005
Y1 - 2005
N2 - Energy metabolic pathways are intimately linked to cardiac physiology and are perturbed in disease states. Mitochondrial fatty acid β-oxidation, the primary pathway for ATP production in the healthy heart, is regulated in large part through transcriptional mechanisms by peroxisome proliferator-activated receptors (PPARs). Although controversy surrounds the relative cardiac expression and activity levels of the three PPAR isoforms, α, β/δ and γ, pharmaceutical modulation of PPARs, and by extension, cardiac metabolism and lipid handling, can represent a potential strategy to combat metabolic aspects of heart disease.
AB - Energy metabolic pathways are intimately linked to cardiac physiology and are perturbed in disease states. Mitochondrial fatty acid β-oxidation, the primary pathway for ATP production in the healthy heart, is regulated in large part through transcriptional mechanisms by peroxisome proliferator-activated receptors (PPARs). Although controversy surrounds the relative cardiac expression and activity levels of the three PPAR isoforms, α, β/δ and γ, pharmaceutical modulation of PPARs, and by extension, cardiac metabolism and lipid handling, can represent a potential strategy to combat metabolic aspects of heart disease.
UR - http://www.scopus.com/inward/record.url?scp=33645048176&partnerID=8YFLogxK
U2 - 10.1016/j.ddmec.2005.05.011
DO - 10.1016/j.ddmec.2005.05.011
M3 - Review article
AN - SCOPUS:33645048176
VL - 2
SP - 109
EP - 114
JO - Drug Discovery Today: Disease Mechanisms
JF - Drug Discovery Today: Disease Mechanisms
SN - 1740-6765
IS - 1
ER -