Do PPARs play a role in cardiac hypertrophy and heart failure?

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Energy metabolic pathways are intimately linked to cardiac physiology and are perturbed in disease states. Mitochondrial fatty acid β-oxidation, the primary pathway for ATP production in the healthy heart, is regulated in large part through transcriptional mechanisms by peroxisome proliferator-activated receptors (PPARs). Although controversy surrounds the relative cardiac expression and activity levels of the three PPAR isoforms, α, β/δ and γ, pharmaceutical modulation of PPARs, and by extension, cardiac metabolism and lipid handling, can represent a potential strategy to combat metabolic aspects of heart disease.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalDrug Discovery Today: Disease Mechanisms
Volume2
Issue number1
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

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