Do More with Less? Lobectomy vs. Segmentectomy for Patients with Congenital Pulmonary Malformations

Beatrice Trabalza Marinucci, Cecilia Menna, Paolo Scanagatta, Silvia Fiorelli, Matteo Tiracorrendo, Giuseppe Naldi, Alessandro Inserra, Francesco Macchini, Erino Angelo Rendina, Mohsen Ibrahim

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Congenital Pulmonary Malformations (CPMs) are rare benign lesions potentially causing infective complications and/or malignant transformation, requiring surgery even when asymptomatic. CPMs are rare in adulthood but potentially detected at any age. There is not a consensus on the correct extent of resection in both adults and paediatrics. This retrospective multicentric study aims to identify the appropriate surgical resection to prevent the recurrence of the related respiratory symptoms. Methods: Between 2010 and 2020, a total of 96 patients (adults and pediatrics) underwent surgery for CPMs in 4 centers. A 2:1 propensity score matching (considering sex and lesion side) was performed, identifying 2 groups: 50 patients underwent lobectomy (group A) and 25 sub-lobar resections (group B). Clinical and histopathological characteristics, early and late complications, and symptom recurrence were retrospectively analyzed and compared between the two groups by univariate and multivariate analysis. Results: Patients who underwent lobectomy had a statistically significant lower rate of recurrence (4% vs. 24% of group B, p = 0.014) and a lower rate of intraoperative complications (p = 0.014). Logistic regression identified sub-lobar resection (p = 0.040), intra- and post-operative complications (p = 0.105 and 0.022),and associated developed neoplasm (p = 0.062) as possible risk factors for symptom recurrence after surgery. Conclusions: Pulmonary lobectomy seems to be the most effective surgical treatment for CPMs, guaranteeing the stable remission of symptoms and a lower rate of intra- and postoperative complications. To our knowledge, this is one of the largest studies comparing lobectomy and sub-lobar resections in patients affected by CPMs, considering the low incidence worldwide.

Original languageEnglish
Article number5237
JournalJournal of Clinical Medicine
Volume12
Issue number16
DOIs
StatePublished - Aug 2023

Keywords

  • Congenital Pulmonary Malformations
  • congenital cystic adenomatoid malformation
  • lobectomy
  • pulmonary sequestration
  • thoracic surgery

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