@article{fcebd443d35e4ebf985aff3642d38c01,
title = "Do Current Animal Models of Intracerebral Hemorrhage Mirror the Human Pathology?",
abstract = "Although intracerebral hemorrhage (ICH) has no proven treatment, well-designed studies using animal models of ICH may lead to the development of novel therapies. We briefly review current animal models of ICH. Furthermore, we discuss how these models may be utilized and targeted to facilitate translation of preclinical findings to the clinical arena.",
keywords = "Animal models, Intracerebral hemorrhage, Stroke, Translation",
author = "Opeolu Adeoye and Clark, {Joseph F.} and Pooja Khatri and Wagner, {Kenneth R.} and Mario Zuccarello and Pyne-Geithman, {Gail J.}",
note = "Funding Information: Intracerebral hemorrhage (ICH) occurs in an estimated two million persons worldwide each year [1–4] and has no proven treatment. There is an urgent need for preclinical/animal studies that may be translated to human trials for ICH therapies. This need is recognized by the National Institutes of Health (NIH) [5], the American Heart Association (AHA) [2], and is increasingly being addressed by investigators [6]. Although some therapies for ICH that were promising preclinically have subsequently been studied in large human trials, none have been successfully replicated in human studies [7, 8]. Over a decade ago, similar concerns in ischemic stroke led to development of the Stroke Therapy Academic Industry Roundtable (STAIR) recommendations, which were intended to improve translation of preclinical studies of purported therapies in ischemic stroke. The most recent STAIR update continues to emphasize improved preclinical models of ischemic stroke and a need for well-designed, controlled preclinical studies to improve translation of preclinical therapies to the human condition [9]. While the methodological recommendations of the STAIR Committees are widely applicable to translational research, the goal of this article is to address issues specific to translational studies of ICH. Therefore, we review common animal models of ICH and discuss how the models may be best utilized to improve care of the human condition. We hope this provides a reference for both the clinician, who may be unfamiliar with available animal models of ICH, and for the basic scientist, as an updated review of salient clinical features of the human disease.",
year = "2011",
month = mar,
doi = "10.1007/s12975-010-0037-1",
language = "English",
volume = "2",
pages = "17--25",
journal = "Translational Stroke Research",
issn = "1868-4483",
number = "1",
}