@article{ec401ebd1acc49358b5f2af47d2fedc5,
title = "DNMT3A Haploinsufficiency Results in Behavioral Deficits and Global Epigenomic Dysregulation Shared across Neurodevelopmental Disorders",
abstract = "Christian et al. find that neurodevelopmental disease-associated DNMT3A mutations have shared neuronal DNA methylation deposition deficits. DNMT3AKO/+ mice display reduced global non-CG DNA methylation, behavior, and growth phenotypes relevant to human disease. Transcriptomic and epigenomic changes in these mice overlap models of Rett syndrome and autism, suggesting convergent pathology.",
keywords = "Autism, DNA methylation, DNMT3A, MeCP2, Rett Syndrome, TBRS, cerebral cortex, enhancer, intellectual disability, non-CG methylation",
author = "Christian, {Diana L.} and Wu, {Dennis Y.} and Martin, {Jenna R.} and Moore, {J. Russell} and Liu, {Yiran R.} and Clemens, {Adam W.} and Nettles, {Sabin A.} and Kirkland, {Nicole M.} and Thomas Papouin and Hill, {Cheryl A.} and Wozniak, {David F.} and Dougherty, {Joseph D.} and Gabel, {Harrison W.}",
note = "Funding Information: We thank J. Hoisington-Lopez and M. Crosby at the Center for Genome Sciences for sequencing support; S. Maloney, K. McCullough, and M. Rieger for assistance with USV experiments; and J. Edwards, J. Goodman, J. Yi, A. Smith, and T. Ley for discussions. We thank our funding sources: NIH-NCRR award UL1RR024992 ; NIH-NIGMS award T32GM008151 and NIH-NICHD award F31HD100098 (to D.L.C.); NIH-NINDS award F31NS108574 (to A.W.C.); grants from the Klingenstein-Simons Fellowship Fund , the Mathers Foundation , the Brain and Behavior Research Foundation , and the Simons Foundation Autism Research Initiative ; and NIH-NIMH R01MH117405 (to H.W.G.). Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = nov,
day = "24",
doi = "10.1016/j.celrep.2020.108416",
language = "English",
volume = "33",
journal = "Cell Reports",
issn = "2211-1247",
number = "8",
}