TY - JOUR
T1 - DNA/TNA mesoscopic modeling of melting temperatures suggests weaker hydrogen bonding of CG than in DNA/RNA
AU - Muniz, Maria Izabel
AU - Lackey, Hershel H.
AU - Heemstra, Jennifer M.
AU - Weber, Gerald
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/6/16
Y1 - 2020/6/16
N2 - TNA/DNA hybrids share several similarities to RNA/DNA, such as the tendency to form A-type helices and a strong dependency of their thermodynamic properties on purine/pyrimidine ratio. However, unlike RNA/DNA, not much is known about the base-pair properties of TNA. Here, we use a mesoscopic analysis of measured melting temperatures to obtain an estimate of hydrogen bonds and stacking interactions. Our results reveal that the AT base pairs in TNA/DNA have nearly identical hydrogen bond strengths than their counterparts in RNA/DNA, but surprisingly CG turned out to be much weaker despite similar stability.
AB - TNA/DNA hybrids share several similarities to RNA/DNA, such as the tendency to form A-type helices and a strong dependency of their thermodynamic properties on purine/pyrimidine ratio. However, unlike RNA/DNA, not much is known about the base-pair properties of TNA. Here, we use a mesoscopic analysis of measured melting temperatures to obtain an estimate of hydrogen bonds and stacking interactions. Our results reveal that the AT base pairs in TNA/DNA have nearly identical hydrogen bond strengths than their counterparts in RNA/DNA, but surprisingly CG turned out to be much weaker despite similar stability.
KW - DNA/TNA hybrid
KW - DNA/TNA stability
KW - Hydrogen bonds
KW - Peyrard-Bishop DNA model
KW - Stacking interaction
UR - https://www.scopus.com/pages/publications/85083342238
U2 - 10.1016/j.cplett.2020.137413
DO - 10.1016/j.cplett.2020.137413
M3 - Article
AN - SCOPUS:85083342238
SN - 0009-2614
VL - 749
JO - Chemical Physics Letters
JF - Chemical Physics Letters
M1 - 137413
ER -