TY - JOUR
T1 - DNA, sunlight and skin cancer
AU - Taylor, John Stephen
N1 - Funding Information:
Acknowledgments. The majority of this work was supported by PHS Grant R01-CA40463 awarded by the National Cancer Institute, DHHS.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Mutations in the p53 tumor suppressor genes in the most common types of skin cancer occur almost exclusively at dipyrimidine sites and are highly characteristic of UVB light. The UVB in sunlight produces cis-syn dimers and (6–4) products at dipyrimidine sites, the latter of which are isomerized by UVA/B light to their Dewar valence isomers. Which of these photoproduct classes is primarily responsible for the mutagenic and carcinogenic effects of sunlight is unknown and to approach this problem we have been developing methods for the construction and study of DNA containing unique photoproducts. Our studies have led us to a new proposal for the origin of C->T mutations, the principal mutations induced by UVB light in many living systems and the major mutation found in the human p53 gene.
AB - Mutations in the p53 tumor suppressor genes in the most common types of skin cancer occur almost exclusively at dipyrimidine sites and are highly characteristic of UVB light. The UVB in sunlight produces cis-syn dimers and (6–4) products at dipyrimidine sites, the latter of which are isomerized by UVA/B light to their Dewar valence isomers. Which of these photoproduct classes is primarily responsible for the mutagenic and carcinogenic effects of sunlight is unknown and to approach this problem we have been developing methods for the construction and study of DNA containing unique photoproducts. Our studies have led us to a new proposal for the origin of C->T mutations, the principal mutations induced by UVB light in many living systems and the major mutation found in the human p53 gene.
UR - http://www.scopus.com/inward/record.url?scp=0000723716&partnerID=8YFLogxK
U2 - 10.1351/pac199567010183
DO - 10.1351/pac199567010183
M3 - Article
AN - SCOPUS:0000723716
SN - 0033-4545
VL - 67
SP - 183
EP - 190
JO - Pure and Applied Chemistry
JF - Pure and Applied Chemistry
IS - 1
ER -