DNA probe for the identification of Histoplasma capsulatum

E. J. Keath, E. D. Spitzer, A. A. Painter, S. J. Travis, G. S. Kobayashi, G. Medoff

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A 1.85-kilobase HindIII nuclear DNA probe from Histoplasma capsulatum G217B detected polymorphic restriction fragments within whole-cell DNA from different clinical isolates of H. capsulatum, consistent with the previous system of classification. The probe failed to hybridize to DNA from Blastomyces dermatitidis, Candida spp., Saccharomyces cerevisiae, Sepedonium chrysospermum, and Chrysosporium keratinophilum under low-stringency conditions and therefore may have values as a diagnostic reagent to identify H. capsulatum.

Original languageEnglish
Pages (from-to)2369-2372
Number of pages4
JournalJournal of clinical microbiology
Volume27
Issue number10
DOIs
StatePublished - 1989

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