DNA Photolyase Repairs the trans-syn Cyclobutane Thymine Dimer

Sang Tae Kim, Khushbeer Malhotra, Aziz Sancar, Colin A. Smith, John Stephen Taylor

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


DNA photolyases catalyze the splitting of the cyclobutane ring joining the two dihydropyrimidines of a pyrimidine dimer by a photoinduced electron-transfer reaction. Previous studies concluded that photolyase repairs only the cis-syn form of the eight stereoisomers of the cyclobutane pyrimidine dimer (Pyr[]Pyr). In this study we found that Escherichia coli photolyase binds to the trans-syn-I isomer of T[]T with about 104-fold lower affinity than the cis-syn isomer but it repairs it relatively efficiently.

Original languageEnglish
Pages (from-to)7065-7068
Number of pages4
Issue number28
StatePublished - 1993


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