DNA Origami-Assisted Regioselective Organization of Anisotropic Gold Nanotriangle Clusters

The manipulation of anisotropic nanoparticles, such as gold nanorods and nanoprisms, has attracted great attention in nanotechnology due to their sensitive geometry-dependent properties. However. traditional synthesis and assembly methods for these particles face challenges in size uniformity and higher-order structuring. To address these limitations, this study presents a strategy using DNA origami triangles, not just as templates, but as encapsulating agents for gold nanotriangles (AuNTs). This method enables the construction of diverse nanoparticle clusters with precisely controlled distance and orientation. The formed clusters exhibit unique optical characteristics, demonstrated by UV-visible spectroscopy and supported by finite-difference time domain (FDTD) simulations. The observed shifts in plasmon resonance peaks indicate significant electromagnetic interaction by organizing nanoparticles in proximity and show the potential of this method for creating highly sensitive biosensors and other nanophotonic applications.