DNA damage signals inhibit neutrophil function

Research output: Contribution to journalComment/debate

1 Scopus citations


In this issue of Blood, Harbort et al identify a novel role for DNA damage responses in the regulation of cytokine production and cell death of activated neutrophils.1 They show that reactive oxygen species (ROS) generated by stimulated neutrophils trigger DNA damage signaling, which suppresses proinflammatory functions (see figure). Their work reveals new insights into the control of innate immunity and inflammation.

Original languageEnglish
Pages (from-to)2773-2774
Number of pages2
Issue number26
StatePublished - Dec 24 2015

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