DNA damage responses: Beyond double-strand break repair

Andrea L. Bredemeyer, Barry P. Sleckman

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations


The RAG endonuclease generates DNA double strand breaks during antigen receptor gene assembly, an essential process for B- and T-lymphocyte development. However, a recent study reveals that RAG endonuclease activity affects natural killer cell function, demonstrating that such double strand breaks, and the responses they elicit, may have broad cellular effects.

Original languageEnglish
Pages (from-to)R45-R46
JournalCurrent Biology
Issue number1
StatePublished - Jan 5 2015


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