TY - JOUR
T1 - DNA damage responses
T2 - Beyond double-strand break repair
AU - Bredemeyer, Andrea L.
AU - Sleckman, Barry P.
N1 - Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.
PY - 2015/1/5
Y1 - 2015/1/5
N2 - The RAG endonuclease generates DNA double strand breaks during antigen receptor gene assembly, an essential process for B- and T-lymphocyte development. However, a recent study reveals that RAG endonuclease activity affects natural killer cell function, demonstrating that such double strand breaks, and the responses they elicit, may have broad cellular effects.
AB - The RAG endonuclease generates DNA double strand breaks during antigen receptor gene assembly, an essential process for B- and T-lymphocyte development. However, a recent study reveals that RAG endonuclease activity affects natural killer cell function, demonstrating that such double strand breaks, and the responses they elicit, may have broad cellular effects.
UR - http://www.scopus.com/inward/record.url?scp=84920446398&partnerID=8YFLogxK
U2 - 10.1016/j.cub.2014.11.024
DO - 10.1016/j.cub.2014.11.024
M3 - Short survey
C2 - 25562302
AN - SCOPUS:84920446398
SN - 0960-9822
VL - 25
SP - R45-R46
JO - Current Biology
JF - Current Biology
IS - 1
ER -