TY - JOUR
T1 - DNA damage and decisions
T2 - CtIP coordinates DNA repair and cell cycle checkpoints
AU - You, Zhongsheng
AU - Bailis, Julie M.
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/7
Y1 - 2010/7
N2 - Maintenance of genome stability depends on efficient, accurate repair of DNA damage. DNA double-strand breaks (DSBs) are among the most lethal types of DNA damage, with the potential to cause mutation, chromosomal rearrangement, and genomic instability that could contribute to cancer. DSB damage can be repaired by various pathways including nonhomologous end-joining (NHEJ) and homologous recombination (HR). However, the cellular mechanisms that regulate the choice of repair pathway are not well understood. Recent studies suggest that the tumor suppressor protein CtIP controls the decision to repair DSB damage by HR. It does so by regulating the initiation of DSB end resection after integrating signals from the DNA damage checkpoint response and cell cycle cues.
AB - Maintenance of genome stability depends on efficient, accurate repair of DNA damage. DNA double-strand breaks (DSBs) are among the most lethal types of DNA damage, with the potential to cause mutation, chromosomal rearrangement, and genomic instability that could contribute to cancer. DSB damage can be repaired by various pathways including nonhomologous end-joining (NHEJ) and homologous recombination (HR). However, the cellular mechanisms that regulate the choice of repair pathway are not well understood. Recent studies suggest that the tumor suppressor protein CtIP controls the decision to repair DSB damage by HR. It does so by regulating the initiation of DSB end resection after integrating signals from the DNA damage checkpoint response and cell cycle cues.
UR - http://www.scopus.com/inward/record.url?scp=77954313601&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2010.04.002
DO - 10.1016/j.tcb.2010.04.002
M3 - Review article
C2 - 20444606
AN - SCOPUS:77954313601
VL - 20
SP - 402
EP - 409
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 7
ER -