Eukaryotic cells from yeast to humans use sequential protein kinase reactions to regulate complex cellular functions. Equivalent protein kinases in different pathways have significant sequence homologies; however, little crossover in phosphorylation of substrates between pathways normally occurs. Assembly of kinase complexes and discrimination of substrates provide the selectivity of sequential protein kinase pathways to regulate such diverse cellular functions as osmoregulation, cell-wall biosynthesis, growth and differentiation.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalTrends in biochemical sciences
Issue number6
StatePublished - Jun 1994


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