Divergent quasispecies evolution in de novo hepatitis C virus infection associated with bone marrow transplantation

Weihua Wang, Jianguo Lin, De Tan, Yanjuan Xu, Elizabeth M. Brunt, Xiaofeng Fan, Adrian M. Di Bisceglie

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Quasispecies is a remarkable characteristic of hepatitis C virus (HCV) and has profound roles in HCV biology and clinical practice. The understanding of HCV quasispecies behavior, in particular in acute HCV infection, is valuable for vaccine development and therapeutic interference. However, acute HCV infection is seldom encountered in clinic practice due to its silent onset. In the present study, we reported a unique case of de novo HCV infection associated with the transplantation of bone marrow from a HCV-positive donor. HCV quasispecies diversity was determined in both the donor and the recipient over a 4-year follow-up, accompanied with simultaneous measurement of HCV neutralizing antibody. Detailed genetic and phylogenetic analyses revealed a divergent quasispecies evolution, which was not related to dynamic changes of HCV neutralizing antibody. Instead, our data suggested an essential role of the fitness adaptation of founder viral population in driving such an evolutionary pattern.

Original languageEnglish
Pages (from-to)148-152
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume414
Issue number1
DOIs
StatePublished - Oct 14 2011

Keywords

  • Bone marrow transplantation
  • Hepatitis C
  • Quasispecies

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