TY - JOUR
T1 - Divergent quasispecies evolution in de novo hepatitis C virus infection associated with bone marrow transplantation
AU - Wang, Weihua
AU - Lin, Jianguo
AU - Tan, De
AU - Xu, Yanjuan
AU - Brunt, Elizabeth M.
AU - Fan, Xiaofeng
AU - Di Bisceglie, Adrian M.
PY - 2011/10/14
Y1 - 2011/10/14
N2 - Quasispecies is a remarkable characteristic of hepatitis C virus (HCV) and has profound roles in HCV biology and clinical practice. The understanding of HCV quasispecies behavior, in particular in acute HCV infection, is valuable for vaccine development and therapeutic interference. However, acute HCV infection is seldom encountered in clinic practice due to its silent onset. In the present study, we reported a unique case of de novo HCV infection associated with the transplantation of bone marrow from a HCV-positive donor. HCV quasispecies diversity was determined in both the donor and the recipient over a 4-year follow-up, accompanied with simultaneous measurement of HCV neutralizing antibody. Detailed genetic and phylogenetic analyses revealed a divergent quasispecies evolution, which was not related to dynamic changes of HCV neutralizing antibody. Instead, our data suggested an essential role of the fitness adaptation of founder viral population in driving such an evolutionary pattern.
AB - Quasispecies is a remarkable characteristic of hepatitis C virus (HCV) and has profound roles in HCV biology and clinical practice. The understanding of HCV quasispecies behavior, in particular in acute HCV infection, is valuable for vaccine development and therapeutic interference. However, acute HCV infection is seldom encountered in clinic practice due to its silent onset. In the present study, we reported a unique case of de novo HCV infection associated with the transplantation of bone marrow from a HCV-positive donor. HCV quasispecies diversity was determined in both the donor and the recipient over a 4-year follow-up, accompanied with simultaneous measurement of HCV neutralizing antibody. Detailed genetic and phylogenetic analyses revealed a divergent quasispecies evolution, which was not related to dynamic changes of HCV neutralizing antibody. Instead, our data suggested an essential role of the fitness adaptation of founder viral population in driving such an evolutionary pattern.
KW - Bone marrow transplantation
KW - Hepatitis C
KW - Quasispecies
UR - http://www.scopus.com/inward/record.url?scp=80054059640&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2011.09.041
DO - 10.1016/j.bbrc.2011.09.041
M3 - Article
C2 - 21945614
AN - SCOPUS:80054059640
VL - 414
SP - 148
EP - 152
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -