TY - JOUR
T1 - Distribution of mast cells and their correlation with inflammatory cells around Onchocerca gutturosa, O. tarsicola, O. ochengi, and O. flexuosa
AU - Wildenburg, Gabriele
AU - Plenge-Bönig, Anita
AU - Renz, Alfons
AU - Fischer, Peter
AU - Büttner, Dietrich W.
N1 - Funding Information:
Acknowledgements The authors are grateful to H. Schulz-Key for the O. tarsicola and to D. B. Copeman for the O. gibsoni. They wish to thank I. Albrecht, P. Eggert, and M. Krömer for excellent technical assistance. The project was supported in part by the Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie, Germany (BMBF grant 01KA9201/5).
PY - 1997
Y1 - 1997
N2 - In recent years, bovine Onchocerca species have been used as models for human onchocerciasis in drug screens. They have been suggested for immunology studies and evaluation of vaccine candidates. Therefore, mast cells and their association with other inflammatory cells were studied in five onchocercal species of cattle and deer using immunohistology. Intact mast cells occurred in large numbers in the capsule and septae of nodules, in fibrous tissue adjacent to nonnodular worms, and perivascularly. Inactive and, more frequently, activated and degranulating mast cells were observed within infiltrates in the nodule center or around nonnodular filariae. They were not detected in direct contact with the cuticle of adult worms or of microfilariae or among the macrophages, giant cells, and neutrophils forming the innermost layer around the worms. Eosinophils, but not mast cells, were obviously associated with microfilariae producing females. The distribution, frequency, and activity of mast cells were similar for all five species and O. volvulus.
AB - In recent years, bovine Onchocerca species have been used as models for human onchocerciasis in drug screens. They have been suggested for immunology studies and evaluation of vaccine candidates. Therefore, mast cells and their association with other inflammatory cells were studied in five onchocercal species of cattle and deer using immunohistology. Intact mast cells occurred in large numbers in the capsule and septae of nodules, in fibrous tissue adjacent to nonnodular worms, and perivascularly. Inactive and, more frequently, activated and degranulating mast cells were observed within infiltrates in the nodule center or around nonnodular filariae. They were not detected in direct contact with the cuticle of adult worms or of microfilariae or among the macrophages, giant cells, and neutrophils forming the innermost layer around the worms. Eosinophils, but not mast cells, were obviously associated with microfilariae producing females. The distribution, frequency, and activity of mast cells were similar for all five species and O. volvulus.
UR - http://www.scopus.com/inward/record.url?scp=0031052689&partnerID=8YFLogxK
U2 - 10.1007/s004360050220
DO - 10.1007/s004360050220
M3 - Article
C2 - 9039692
AN - SCOPUS:0031052689
VL - 83
SP - 109
EP - 120
JO - Parasitology Research
JF - Parasitology Research
SN - 0044-3255
IS - 2
ER -