Distributed control in a mean-field cortical network model: Implications for seizure suppression

Shinung Ching, Emery N. Brown, Mark A. Kramer

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Brain electrical stimulation (BES) has long been suggested as a means of controlling pathological brain activity. In epilepsy, control of a spatially localized source, the seizure focus, may normalize neuronal dynamics. Consequently, most BES research has been directed at controlling small, local, neuronal populations. At a higher level, pathological seizure activity can be viewed as a network event that may begin without a clear spatial focus or in multiple sites and spread rapidly through a distributed cortical network. In this paper, we begin to address the implications of local control in a network scenario. To do so, we explore the efficacy of local BES when deployed over a larger-scale neuronal network, for instance, using a grid of stimulating electrodes on the cortex. By introducing a mean-field model of neuronal interactions we are able to identify limitations in network controllability based on physiological constraints that suggest the need for more nuanced network control strategies.

Original languageEnglish
Article number021920
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Issue number2
StatePublished - Aug 21 2012


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