Distinct therapeutic mechanisms of Tau antibodies: Promoting microglial clearance versus blocking neuronal uptake

Keyphrases

• Microglia 100%
• Tau Antibodies 100%
• Neuronal Uptake 100%
• Therapeutic Mechanism 100%
• Alzheimer's Disease 75%
• Recombinant 50%
• Primary Neurons 50%
• Tau Fibrils 50%
• Repeat Domain 50%
• Tau Aggregates 50%
• Disease Progression 25%
• Tauopathy 25%
• Mouse Model 25%
• Frontotemporal Dementia 25%
• Fc Receptor 25%
• Size Dependence 25%
• Heparin 25%
• Size Fraction 25%
• Specific Mechanisms 25%
• Intracerebroventricular Administration 25%
• Therapeutic Antibody 25%
• Antibody Activity 25%
• Active Vaccination 25%
• Extracellular tau 25%
• Aggregate Size 25%
• Neurodegenerative Diseases 25%
• In Vitro Activity 25%
• Transneuronal 25%
• Large Oligomers 25%
• Heparan Sulfate Proteoglycans 25%
• Passive Vaccination 25%
• Anti-tau 25%
• Epitope 25%
• Overexpressing 25%
• Monoclonal Antibody 25%
• P301S 25%
• Negative Control 25%
• BV2 Cells 25%
• Vaccine Research 25%
• Tau Amyloid 25%

Neuroscience

• Alzheimer's Disease 100%
• Microglia 66%
• Oligomer 66%
• Amyloid Protein 66%
• In Vivo 33%
• In Vitro 33%
• Heparin 33%
• Epitope 33%
• Proteoheparan Sulfate 33%
• Monomer 33%
• Frontotemporal Dementia 33%
• Fc Receptor 33%
• Neurodegenerative Disorder 33%
• Monoclonal Antibody 33%
• Therapeutic Antibodies 33%
• Tauopathy 33%

Immunology and Microbiology

• Fibril 100%
• Microglia 40%
• Mouse Model 20%
• Monoclonal Antibody 20%
• Fc Receptor 20%
• Fractionation 20%
• Therapeutic Antibodies 20%
• Epitope 20%
• Proteoglycan 20%