Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice

Alexandra C. Walls; Laura A. VanBlargan; Kai Wu; Angela Choi; Mary Jane Navarro; Diana Lee; Laura Avena; Daniela Montes Berrueta; Minh N. Pham; Sayda Elbashir; John C. Kraft; Marcos C. Miranda; Elizabeth Kepl; Max Johnson; Alyssa Blackstone; Kaitlin Sprouse; Brooke Fiala; Megan A. O'Connor; Natalie Brunette; Prabhu S. Arunachalam; Lisa Shirreff; Kenneth Rogers; Lauren Carter; Deborah H. Fuller; Francois Villinger; Bali Pulendran; Michael S. Diamond; Darin K. Edwards; Neil P. King; David Veesler

doi:10.1016/j.celrep.2022.111299

Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice

Alexandra C. Walls, Laura A. VanBlargan, Kai Wu, Angela Choi, Mary Jane Navarro, Diana Lee, Laura Avena, Daniela Montes Berrueta, Minh N. Pham, Sayda Elbashir, John C. Kraft, Marcos C. Miranda, Elizabeth Kepl, Max Johnson, Alyssa Blackstone, Kaitlin Sprouse, Brooke Fiala, Megan A. O'Connor, Natalie Brunette, Prabhu S. ArunachalamLisa Shirreff, Kenneth Rogers, Lauren Carter, Deborah H. Fuller, Francois Villinger, Bali Pulendran, Michael S. Diamond, Darin K. Edwards, Neil P. King, David Veesler

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8 Scopus citations

Abstract

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019 has led to the development of a large number of vaccines, several of which are now approved for use in humans. Understanding vaccine-elicited antibody responses against emerging SARS-CoV-2 variants of concern (VOCs) in real time is key to inform public health policies. Serum neutralizing antibody titers are the current best correlate of protection from SARS-CoV-2 challenge in non-human primates and a key metric to understand immune evasion of VOCs. We report that vaccinated BALB/c mice do not recapitulate faithfully the breadth and potency of neutralizing antibody responses elicited by various vaccine platforms against VOCs, compared with non-human primates or humans, suggesting caution should be exercised when interpreting data obtained with this animal model.

Original language	English
Article number	111299
Journal	Cell Reports
Volume	40
Issue number	9
DOIs	https://doi.org/10.1016/j.celrep.2022.111299
State	Published - Aug 30 2022

Keywords

COVID-19
CP: Immunology
CP: Microbiology
SARS-CoV-2
antibodies
humans
mouse
non-human primates
vaccines

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10.1016/j.celrep.2022.111299

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Walls, A. C., VanBlargan, L. A., Wu, K., Choi, A., Navarro, M. J., Lee, D., Avena, L., Berrueta, D. M., Pham, M. N., Elbashir, S., Kraft, J. C., Miranda, M. C., Kepl, E., Johnson, M., Blackstone, A., Sprouse, K., Fiala, B., O'Connor, M. A., Brunette, N., ... Veesler, D. (2022). Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice. Cell Reports, 40(9), Article 111299. https://doi.org/10.1016/j.celrep.2022.111299

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title = "Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice",

abstract = "The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019 has led to the development of a large number of vaccines, several of which are now approved for use in humans. Understanding vaccine-elicited antibody responses against emerging SARS-CoV-2 variants of concern (VOCs) in real time is key to inform public health policies. Serum neutralizing antibody titers are the current best correlate of protection from SARS-CoV-2 challenge in non-human primates and a key metric to understand immune evasion of VOCs. We report that vaccinated BALB/c mice do not recapitulate faithfully the breadth and potency of neutralizing antibody responses elicited by various vaccine platforms against VOCs, compared with non-human primates or humans, suggesting caution should be exercised when interpreting data obtained with this animal model.",

keywords = "COVID-19, CP: Immunology, CP: Microbiology, SARS-CoV-2, antibodies, humans, mouse, non-human primates, vaccines",

author = "Walls, {Alexandra C.} and VanBlargan, {Laura A.} and Kai Wu and Angela Choi and Navarro, {Mary Jane} and Diana Lee and Laura Avena and Berrueta, {Daniela Montes} and Pham, {Minh N.} and Sayda Elbashir and Kraft, {John C.} and Miranda, {Marcos C.} and Elizabeth Kepl and Max Johnson and Alyssa Blackstone and Kaitlin Sprouse and Brooke Fiala and O'Connor, {Megan A.} and Natalie Brunette and Arunachalam, {Prabhu S.} and Lisa Shirreff and Kenneth Rogers and Lauren Carter and Fuller, {Deborah H.} and Francois Villinger and Bali Pulendran and Diamond, {Michael S.} and Edwards, {Darin K.} and King, {Neil P.} and David Veesler",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2022",

month = aug,

day = "30",

doi = "10.1016/j.celrep.2022.111299",

language = "English",

volume = "40",

journal = "Cell Reports",

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Walls, AC, VanBlargan, LA, Wu, K, Choi, A, Navarro, MJ, Lee, D, Avena, L, Berrueta, DM, Pham, MN, Elbashir, S, Kraft, JC, Miranda, MC, Kepl, E, Johnson, M, Blackstone, A, Sprouse, K, Fiala, B, O'Connor, MA, Brunette, N, Arunachalam, PS, Shirreff, L, Rogers, K, Carter, L, Fuller, DH, Villinger, F, Pulendran, B, Diamond, MS, Edwards, DK, King, NP & Veesler, D 2022, 'Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice', Cell Reports, vol. 40, no. 9, 111299. https://doi.org/10.1016/j.celrep.2022.111299

TY - JOUR

T1 - Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice

AU - Walls, Alexandra C.

AU - VanBlargan, Laura A.

AU - Wu, Kai

AU - Choi, Angela

AU - Navarro, Mary Jane

AU - Lee, Diana

AU - Avena, Laura

AU - Berrueta, Daniela Montes

AU - Pham, Minh N.

AU - Elbashir, Sayda

AU - Kraft, John C.

AU - Miranda, Marcos C.

AU - Kepl, Elizabeth

AU - Johnson, Max

AU - Blackstone, Alyssa

AU - Sprouse, Kaitlin

AU - Fiala, Brooke

AU - O'Connor, Megan A.

AU - Brunette, Natalie

AU - Arunachalam, Prabhu S.

AU - Shirreff, Lisa

AU - Rogers, Kenneth

AU - Carter, Lauren

AU - Fuller, Deborah H.

AU - Villinger, Francois

AU - Pulendran, Bali

AU - Diamond, Michael S.

AU - Edwards, Darin K.

AU - King, Neil P.

AU - Veesler, David

PY - 2022/8/30

Y1 - 2022/8/30

N2 - The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019 has led to the development of a large number of vaccines, several of which are now approved for use in humans. Understanding vaccine-elicited antibody responses against emerging SARS-CoV-2 variants of concern (VOCs) in real time is key to inform public health policies. Serum neutralizing antibody titers are the current best correlate of protection from SARS-CoV-2 challenge in non-human primates and a key metric to understand immune evasion of VOCs. We report that vaccinated BALB/c mice do not recapitulate faithfully the breadth and potency of neutralizing antibody responses elicited by various vaccine platforms against VOCs, compared with non-human primates or humans, suggesting caution should be exercised when interpreting data obtained with this animal model.

AB - The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019 has led to the development of a large number of vaccines, several of which are now approved for use in humans. Understanding vaccine-elicited antibody responses against emerging SARS-CoV-2 variants of concern (VOCs) in real time is key to inform public health policies. Serum neutralizing antibody titers are the current best correlate of protection from SARS-CoV-2 challenge in non-human primates and a key metric to understand immune evasion of VOCs. We report that vaccinated BALB/c mice do not recapitulate faithfully the breadth and potency of neutralizing antibody responses elicited by various vaccine platforms against VOCs, compared with non-human primates or humans, suggesting caution should be exercised when interpreting data obtained with this animal model.

KW - COVID-19

KW - CP: Immunology

KW - CP: Microbiology

KW - SARS-CoV-2

KW - antibodies

KW - humans

KW - mouse

KW - non-human primates

KW - vaccines

UR - http://www.scopus.com/inward/record.url?scp=85136270433&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2022.111299

DO - 10.1016/j.celrep.2022.111299

M3 - Article

C2 - 35988541

AN - SCOPUS:85136270433

SN - 2211-1247

VL - 40

JO - Cell Reports

JF - Cell Reports

IS - 9

M1 - 111299

ER -

Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice

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Keywords

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