Distinct roles for direct and indirect pathway striatal neurons in reinforcement

Alexxai V. Kravitz, Lynne D. Tye, Anatol C. Kreitzer

Research output: Contribution to journalArticle

489 Scopus citations

Abstract

Dopamine signaling is implicated in reinforcement learning, but the neural substrates targeted by dopamine are poorly understood. We bypassed dopamine signaling itself and tested how optogenetic activation of dopamine D1 or D2 receptor-expressing striatal projection neurons influenced reinforcement learning in mice. Stimulating D1 receptor-expressing neurons induced persistent reinforcement, whereas stimulating D2 receptor-expressing neurons induced transient punishment, indicating that activation of these circuits is sufficient to modify the probability of performing future actions.

Original languageEnglish
Pages (from-to)816-818
Number of pages3
JournalNature neuroscience
Volume15
Issue number6
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

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