Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells

Patrick Fernandes Rodrigues, Llucia Alberti-Servera, Anna Eremin, Gary E. Grajales-Reyes, Robert Ivanek, Roxane Tussiwand

Research output: Contribution to journalArticlepeer-review

181 Scopus citations


Plasmacytoid dendritic cells (pDCs) are an immune subset devoted to the production of high amounts of type 1 interferons in response to viral infections. Whereas conventional dendritic cells (cDCs) originate mostly from a common dendritic cell progenitor (CDP), pDCs have been shown to develop from both CDPs and common lymphoid progenitors. Here, we found that pDCs developed predominantly from IL-7R + lymphoid progenitor cells. Expression of SiglecH and Ly6D defined pDC lineage commitment along the lymphoid branch. Transcriptional characterization of SiglecH + Ly6D + precursors indicated that pDC development requires high expression of the transcription factor IRF8, whereas pDC identity relies on TCF4. RNA sequencing of IL-7R + lymphoid and CDP-derived pDCs mirrored the heterogeneity of mature pDCs observed in single-cell analysis. Both mature pDC subsets are able to secrete type 1 interferons, but only myeloid-derived pDCs share with cDCs their ability to process and present antigen.

Original languageEnglish
Pages (from-to)711-722
Number of pages12
JournalNature immunology
Issue number7
StatePublished - Jul 1 2018


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