Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons

Jason D. Ulrich, Man Su Kim, Patrick R. Houlihan, Leonid P. Shutov, Durga P. Mohapatra, Stefan Strack, Yuriy M. Usachev

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Background: Ca2+/calcineurin-dependent transcription factor NFAT regulates many neuronal functions. Results: Depolarization/Ca2+ influx-induced activation and nuclear translocation are markedly faster and stronger for NFATc3 than NFATc4 in neurons, which is determined in part by SP-containing regions of NFATc3 and NFATc4. Conclusion: Activation of NFATc3 and NFATc4 is distinctly regulated in neurons. Significance: The distinct regulation of NFATc3 and NFATc4 may underlie isoform-specific NFAT functions in neurons.

Original languageEnglish
Pages (from-to)37594-37609
Number of pages16
JournalJournal of Biological Chemistry
Volume287
Issue number45
DOIs
StatePublished - Nov 2 2012

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