Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons

Jason D. Ulrich; Man Su Kim; Patrick R. Houlihan; Leonid P. Shutov; Durga P. Mohapatra; Stefan Strack; Yuriy M. Usachev

doi:10.1074/jbc.M112.365197

Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons

Jason D. Ulrich, Man Su Kim, Patrick R. Houlihan, Leonid P. Shutov, Durga P. Mohapatra, Stefan Strack, Yuriy M. Usachev

Hope Center for Neurological Disorders

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Background: Ca²⁺/calcineurin-dependent transcription factor NFAT regulates many neuronal functions. Results: Depolarization/Ca²⁺ influx-induced activation and nuclear translocation are markedly faster and stronger for NFATc3 than NFATc4 in neurons, which is determined in part by SP-containing regions of NFATc3 and NFATc4. Conclusion: Activation of NFATc3 and NFATc4 is distinctly regulated in neurons. Significance: The distinct regulation of NFATc3 and NFATc4 may underlie isoform-specific NFAT functions in neurons.

Original language	English
Pages (from-to)	37594-37609
Number of pages	16
Journal	Journal of Biological Chemistry
Volume	287
Issue number	45
DOIs	https://doi.org/10.1074/jbc.M112.365197
State	Published - Nov 2 2012

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title = "Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons",

abstract = "Background: Ca2+/calcineurin-dependent transcription factor NFAT regulates many neuronal functions. Results: Depolarization/Ca2+ influx-induced activation and nuclear translocation are markedly faster and stronger for NFATc3 than NFATc4 in neurons, which is determined in part by SP-containing regions of NFATc3 and NFATc4. Conclusion: Activation of NFATc3 and NFATc4 is distinctly regulated in neurons. Significance: The distinct regulation of NFATc3 and NFATc4 may underlie isoform-specific NFAT functions in neurons.",

author = "Ulrich, {Jason D.} and Kim, {Man Su} and Houlihan, {Patrick R.} and Shutov, {Leonid P.} and Mohapatra, {Durga P.} and Stefan Strack and Usachev, {Yuriy M.}",

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T1 - Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons

AU - Ulrich, Jason D.

AU - Kim, Man Su

AU - Houlihan, Patrick R.

AU - Shutov, Leonid P.

AU - Mohapatra, Durga P.

AU - Strack, Stefan

AU - Usachev, Yuriy M.

PY - 2012/11/2

Y1 - 2012/11/2

N2 - Background: Ca2+/calcineurin-dependent transcription factor NFAT regulates many neuronal functions. Results: Depolarization/Ca2+ influx-induced activation and nuclear translocation are markedly faster and stronger for NFATc3 than NFATc4 in neurons, which is determined in part by SP-containing regions of NFATc3 and NFATc4. Conclusion: Activation of NFATc3 and NFATc4 is distinctly regulated in neurons. Significance: The distinct regulation of NFATc3 and NFATc4 may underlie isoform-specific NFAT functions in neurons.

AB - Background: Ca2+/calcineurin-dependent transcription factor NFAT regulates many neuronal functions. Results: Depolarization/Ca2+ influx-induced activation and nuclear translocation are markedly faster and stronger for NFATc3 than NFATc4 in neurons, which is determined in part by SP-containing regions of NFATc3 and NFATc4. Conclusion: Activation of NFATc3 and NFATc4 is distinctly regulated in neurons. Significance: The distinct regulation of NFATc3 and NFATc4 may underlie isoform-specific NFAT functions in neurons.

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AN - SCOPUS:84868316950

SN - 0021-9258

VL - 287

SP - 37594

EP - 37609

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 45

ER -

Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons

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