Distal nerve transfers: A biology-based rationale

Justin M. Brown, Manish N. Shah, Susan E. Mackinnon

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

Peripheral nerve injuries can result in devastating numbness and paralysis. Surgical repair strategies have historically focused on restoring the original anatomy with interposition grafts. Distal nerve transfers are becoming a more common strategy in the repair of nerve deficits as these interventions can restore function in months as opposed to more than a year with nerve grafts. The changes that take place over time in the cell body, distal nerve, and target organ after axotomy can compromise the results of traditional graft placement and may at times be better addressed with the use of distal nerve transfers. A carefully devised nerve transfer offers restoration of function with minimal (if any) detectable deficits at the donor site. A new understanding of cortical plasticity along with patient reeducation allow for good return of strength and function after nerve transfer.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalNeurosurgical focus
Volume26
Issue number2
DOIs
StatePublished - 2009

Keywords

  • Brachial plexus injury
  • Distal nerve transfer
  • Nerve graft
  • Plasticity

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