Dissonance Strikes a Chord in Stilbene Synthesizers

Cynthia K. Holland, Barbara Cascella, Joseph M. Jez

Research output: Contribution to journalShort surveypeer-review


In this issue of Cell Chemical Biology, Mori et al. (2016) combine X-ray crystallography and biochemistry to discover a new mechanism for stilbene synthesis in bacteria. The dialkyl-condensing enzyme StlD catalyzes formation of cyclohexanediones using a non-canonical β-ketosynthase active site. Aromatization by StlC completes production of the stilbene product.

Original languageEnglish
Pages (from-to)1440-1441
Number of pages2
JournalCell Chemical Biology
Issue number12
StatePublished - Dec 22 2016


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