Disseminated cryptococcosis with brain involvement in patients with chronic lymphoid malignancies on ibrutinib

Julia A. Messina; Eileen K. Maziarz; Andrej Spec; Dimitrios P. Kontoyiannis; John R. Perfect

doi:10.1093/oid/ofw261

Disseminated cryptococcosis with brain involvement in patients with chronic lymphoid malignancies on ibrutinib

Julia A. Messina
, Eileen K. Maziarz
, Andrej Spec
, Dimitrios P. Kontoyiannis
, John R. Perfect

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

We report 2 cases of disseminated cryptococcosis with central nervous system involvement in patients with chronic lymphoid malignancies occurring within 1 month of starting on ibrutinib. Characteristically, in both cases, no inflammation was seen in the cerebrospinal fluid. Central nervous system mycoses should be considered as a potential complication of ibrutinib.

Original language	English
Article number	ofw261
Journal	Open Forum Infectious Diseases
Volume	4
Issue number	1
DOIs	https://doi.org/10.1093/oid/ofw261
State	Published - 2017

Keywords

CARD9
Central nervous system mycosis
Chronic lymphoid malignancies
Cryptococcosis
Ibrutinib

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10.1093/oid/ofw261

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title = "Disseminated cryptococcosis with brain involvement in patients with chronic lymphoid malignancies on ibrutinib",

abstract = "We report 2 cases of disseminated cryptococcosis with central nervous system involvement in patients with chronic lymphoid malignancies occurring within 1 month of starting on ibrutinib. Characteristically, in both cases, no inflammation was seen in the cerebrospinal fluid. Central nervous system mycoses should be considered as a potential complication of ibrutinib.",

keywords = "CARD9, Central nervous system mycosis, Chronic lymphoid malignancies, Cryptococcosis, Ibrutinib",

author = "Messina, \{Julia A.\} and Maziarz, \{Eileen K.\} and Andrej Spec and Kontoyiannis, \{Dimitrios P.\} and Perfect, \{John R.\}",

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AU - Kontoyiannis, Dimitrios P.

AU - Perfect, John R.

N1 - Publisher Copyright: © The Author 2017.

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AB - We report 2 cases of disseminated cryptococcosis with central nervous system involvement in patients with chronic lymphoid malignancies occurring within 1 month of starting on ibrutinib. Characteristically, in both cases, no inflammation was seen in the cerebrospinal fluid. Central nervous system mycoses should be considered as a potential complication of ibrutinib.

KW - CARD9

KW - Central nervous system mycosis

KW - Chronic lymphoid malignancies

KW - Cryptococcosis

KW - Ibrutinib

UR - https://www.scopus.com/pages/publications/85014174128

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M3 - Article

AN - SCOPUS:85014174128

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Disseminated cryptococcosis with brain involvement in patients with chronic lymphoid malignancies on ibrutinib

Abstract

Keywords

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