Dissecting the biophysics and biology of intrinsically disordered proteins

Priya R. Banerjee; Alex S. Holehouse; Richard Kriwacki; Paul Robustelli; Hao Jiang; Alexander I. Sobolevsky; Jennifer M. Hurley; Joshua T. Mendell

doi:10.1016/j.tibs.2023.10.002

Dissecting the biophysics and biology of intrinsically disordered proteins

Priya R. Banerjee, Alex S. Holehouse, Richard Kriwacki, Paul Robustelli, Hao Jiang, Alexander I. Sobolevsky, Jennifer M. Hurley, Joshua T. Mendell

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Abstract

Intrinsically disordered regions (IDRs) within human proteins play critical roles in cellular information processing, including signaling, transcription, stress response, DNA repair, genome organization, and RNA processing. Here, we summarize current challenges in the field and propose cutting-edge approaches to address them in physiology and disease processes, with a focus on cancer.

Original language	English
Pages (from-to)	101-104
Number of pages	4
Journal	Trends in biochemical sciences
Volume	49
Issue number	2
DOIs	https://doi.org/10.1016/j.tibs.2023.10.002
State	Published - Feb 2024

Keywords

cancer
condensates
phase separation
single-molecule microscopy

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10.1016/j.tibs.2023.10.002

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title = "Dissecting the biophysics and biology of intrinsically disordered proteins",

abstract = "Intrinsically disordered regions (IDRs) within human proteins play critical roles in cellular information processing, including signaling, transcription, stress response, DNA repair, genome organization, and RNA processing. Here, we summarize current challenges in the field and propose cutting-edge approaches to address them in physiology and disease processes, with a focus on cancer.",

keywords = "cancer, condensates, phase separation, single-molecule microscopy",

author = "Banerjee, {Priya R.} and Holehouse, {Alex S.} and Richard Kriwacki and Paul Robustelli and Hao Jiang and Sobolevsky, {Alexander I.} and Hurley, {Jennifer M.} and Mendell, {Joshua T.}",

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AU - Banerjee, Priya R.

AU - Holehouse, Alex S.

AU - Kriwacki, Richard

AU - Robustelli, Paul

AU - Jiang, Hao

AU - Sobolevsky, Alexander I.

AU - Hurley, Jennifer M.

AU - Mendell, Joshua T.

PY - 2024/2

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AB - Intrinsically disordered regions (IDRs) within human proteins play critical roles in cellular information processing, including signaling, transcription, stress response, DNA repair, genome organization, and RNA processing. Here, we summarize current challenges in the field and propose cutting-edge approaches to address them in physiology and disease processes, with a focus on cancer.

KW - cancer

KW - condensates

KW - phase separation

KW - single-molecule microscopy

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ER -

Dissecting the biophysics and biology of intrinsically disordered proteins

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Keywords

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