@article{c918291098eb49f8a82dde9d48d64e97,
title = "Dissecting systemic control of metabolism and aging in the NAD World: The importance of SIRT1 and NAMPT-mediated NAD biosynthesis",
abstract = "Many countries are facing social and economic problems due to increased elderly demographics. With these demands, it is now critical to understand the fundamental regulatory mechanism for aging and longevity in mammals. Our studies on the mammalian NAD-dependent deacetylase SIRT1 and nicotinamide phosphoribosyltransferase (NAMPT)-mediated systemic NAD biosynthesis led us to propose a comprehensive model for the systemic regulatory network connecting metabolism and aging, termed the {"}NAD World{"}. In this article, I will discuss the importance of SIRT1 and NAMPT-mediated NAD biosynthesis in the NAD World and the system dynamics of this hierarchical network for the connection between metabolism and aging.",
keywords = "Aging, Longevity, NAD World, NAD biosynthesis, NAMPT, SIRT1",
author = "Imai, {Shin Ichiro}",
note = "Funding Information: I apologize to those whose work is not cited due to space limitations. I thank members of the Imai lab for critical reading and comments on this manuscript. This work was supported in part by the National Institute on Aging ( AG02150 ), the National Heart, Lung, and Blood Institute ( HL097817 ), the Ellison Medical Foundation, the Longer Life Foundation, and the Diabetes Research and Training Center to S.I. and by institutional support from the Washington University Nutrition Obesity Research Center ( P30DK056341 ) and the Washington University Diabetes Research and Training Center ( DK20579 ). S.I. serves as a scientific advisory board member for Sirtris, a GSK company.",
year = "2011",
month = jun,
day = "6",
doi = "10.1016/j.febslet.2011.04.060",
language = "English",
volume = "585",
pages = "1657--1662",
journal = "FEBS Letters",
issn = "0014-5793",
number = "11",
}