TY - JOUR
T1 - Disruption of Large-Scale Brain Systems in Advanced Aging
AU - Andrews-Hanna, Jessica R.
AU - Snyder, Abraham Z.
AU - Vincent, Justin L.
AU - Lustig, Cindy
AU - Head, Denise
AU - Raichle, Marcus E E.
AU - Buckner, Randy L.
PY - 2007/12/6
Y1 - 2007/12/6
N2 - Cognitive decline is commonly observed in advanced aging even in the absence of disease. Here we explore the possibility that normal aging is accompanied by disruptive alterations in the coordination of large-scale brain systems that support high-level cognition. In 93 adults aged 18 to 93, we demonstrate that aging is characterized by marked reductions in normally present functional correlations within two higher-order brain systems. Anterior to posterior components within the default network were most severely disrupted with age. Furthermore, correlation reductions were severe in older adults free from Alzheimer's disease (AD) pathology as determined by amyloid imaging, suggesting that functional disruptions were not the result of AD. Instead, reduced correlations were associated with disruptions in white matter integrity and poor cognitive performance across a range of domains. These results suggest that cognitive decline in normal aging arises from functional disruption in the coordination of large-scale brain systems that support cognition.
AB - Cognitive decline is commonly observed in advanced aging even in the absence of disease. Here we explore the possibility that normal aging is accompanied by disruptive alterations in the coordination of large-scale brain systems that support high-level cognition. In 93 adults aged 18 to 93, we demonstrate that aging is characterized by marked reductions in normally present functional correlations within two higher-order brain systems. Anterior to posterior components within the default network were most severely disrupted with age. Furthermore, correlation reductions were severe in older adults free from Alzheimer's disease (AD) pathology as determined by amyloid imaging, suggesting that functional disruptions were not the result of AD. Instead, reduced correlations were associated with disruptions in white matter integrity and poor cognitive performance across a range of domains. These results suggest that cognitive decline in normal aging arises from functional disruption in the coordination of large-scale brain systems that support cognition.
KW - HUMDISEASE
KW - SYSNEURO
UR - http://www.scopus.com/inward/record.url?scp=36549068174&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2007.10.038
DO - 10.1016/j.neuron.2007.10.038
M3 - Article
C2 - 18054866
AN - SCOPUS:36549068174
SN - 0896-6273
VL - 56
SP - 924
EP - 935
JO - Neuron
JF - Neuron
IS - 5
ER -