Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome

Paul H. Kim, Jennings Luu, Patrick Heizer, Yiping Tu, Thomas A. Weston, Natalie Chen, Christopher Lim, Robert L. Li, Po Yu Lin, James C.Y. Dunn, Didier Hodzic, Stephen G. Young, Loren G. Fong

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Hutchinson-Gilford progeria syndrome is a disorder of premature aging in children caused by de novo mutations in LMNA that lead to the synthesis of an internally truncated form of prelamin A (commonly called progerin). The production of progerin causes multiple disease phenotypes, including an unusual vascular phenotype characterized by the loss of smooth muscle cells in the arterial media and fibrosis of the adventitia. We show that progerin expression, combined with mechanical stress, promotes smooth muscle cell death. Disrupting the linker of the nucleoskeleton and cytoskeleton (LINC) complex in smooth muscle cells ameliorates the toxic effects of progerin on smooth muscle cells and limits the accompanying adventitial fibrosis.

Original languageEnglish
Article numbereaat7163
JournalScience translational medicine
Volume10
Issue number460
DOIs
StatePublished - Sep 26 2018

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