TY - JOUR
T1 - Disparity in the cytocochleogram and the electrocochleogram in aging LP/j and a/j inbred mice
AU - Chole, Richard A.
AU - Henry, Kenneth R.
PY - 1983
Y1 - 1983
N2 - The auditory systems of aging LP/J and A/J inbred mice were studied using electrocochleography (AP thresholds) and surface preparation cytocochleography. Both strains showed marked age-related auditory threshold elevation, the LP/J demonstrating more pronounced elevation with age than the A/J. Surprisingly, the cytocochleograms showed the opposite relationship: the A/J strain had more loss of hair cells than the LP/J. The elevation of AP thresholds of the LP/J mouse was far out of proportion to the expected auditory deficit on the basis of the cytocochleogram alone. Auditory deficits in the aging LP/J mouse must be due to factors other than anatomical loss of sensory cells.
AB - The auditory systems of aging LP/J and A/J inbred mice were studied using electrocochleography (AP thresholds) and surface preparation cytocochleography. Both strains showed marked age-related auditory threshold elevation, the LP/J demonstrating more pronounced elevation with age than the A/J. Surprisingly, the cytocochleograms showed the opposite relationship: the A/J strain had more loss of hair cells than the LP/J. The elevation of AP thresholds of the LP/J mouse was far out of proportion to the expected auditory deficit on the basis of the cytocochleogram alone. Auditory deficits in the aging LP/J mouse must be due to factors other than anatomical loss of sensory cells.
KW - Electrocochleography
KW - Genetics and hearing
KW - Hair cells
KW - Presbyacusis
KW - Progressive hearing loss
KW - Sensorineural hearing loss
UR - http://www.scopus.com/inward/record.url?scp=0020577742&partnerID=8YFLogxK
U2 - 10.3109/00206098309072798
DO - 10.3109/00206098309072798
M3 - Article
C2 - 6615343
AN - SCOPUS:0020577742
VL - 22
SP - 384
EP - 392
JO - International Journal of Audiology
JF - International Journal of Audiology
SN - 1499-2027
IS - 4
ER -