TY - CHAP
T1 - Disorders of neutrophil function
T2 - An overview
AU - Dinauer, Mary C.
PY - 2014
Y1 - 2014
N2 - Primary disorders of neutrophil function result from impairment in neutrophil responses that are critical for host defense. This chapter summarizes inherited disorders of neutrophils that cause defects in neutrophil adhesion, migration, and oxidative killing. These include the leukocyte adhesion deficiencies, actin defects, and other disorders of chemotaxis, hyperimmunoglobulin E syndrome, Chédiak-Higashi syndrome, neutrophil-specific granule deficiency, chronic granulomatous disease, and myeloperoxidase deficiency. Diagnostic tests and treatment approaches are also summarized for each neutrophil disorder.
AB - Primary disorders of neutrophil function result from impairment in neutrophil responses that are critical for host defense. This chapter summarizes inherited disorders of neutrophils that cause defects in neutrophil adhesion, migration, and oxidative killing. These include the leukocyte adhesion deficiencies, actin defects, and other disorders of chemotaxis, hyperimmunoglobulin E syndrome, Chédiak-Higashi syndrome, neutrophil-specific granule deficiency, chronic granulomatous disease, and myeloperoxidase deficiency. Diagnostic tests and treatment approaches are also summarized for each neutrophil disorder.
KW - Aspergillus species
KW - Chronic granulomatous disease
KW - Chédiak-Higashi syndrome
KW - Hyperimmunoglobulin E
KW - Leukocyte adhesion deficiency
KW - Myeloperoxidase
KW - NADPH oxidase
KW - Neutrophil granule
KW - Staphylococcus aureus
UR - http://www.scopus.com/inward/record.url?scp=84899016657&partnerID=8YFLogxK
U2 - 10.1007/978-1-62703-845-4_30
DO - 10.1007/978-1-62703-845-4_30
M3 - Chapter
C2 - 24504971
AN - SCOPUS:84899016657
SN - 9781627038447
T3 - Methods in Molecular Biology
SP - 501
EP - 515
BT - Neutrophil Methods and Protocols
PB - Humana Press Inc.
ER -