Diseases of the great vessels and the thoracic outlet

Spencer J. Melby, Robert W. Thompson

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The aortic arch and its branches are a common location for the development of atherosclerosis. Similar to atherosclerosis in other areas of the arterial tree, the pathology ranges from mild, nonocclusive intimal thickening to complex atheromata. Complex atheromatous plaques may evolve to a size large enough to encroach upon the lumen, thereby restricting flow, or they may be complicated by intraplaque hemorrhage, ulceration and discharge of atheromatous debris, and surface thrombosis. Well-established clinical risk factors for atherosclerosis include family history, aging, cigarette smoking, hypertension, hyperlipidemia, and diabetes.

Original languageEnglish
Title of host publicationSurgery
Subtitle of host publicationBasic Science and Clinical Evidence: Second Edition
PublisherSpringer New York
Number of pages21
ISBN (Print)9783540297338
StatePublished - 2008


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