Disease and Treatment Patterns among Patients with Pouch-related Conditions in a Cohort of Large Tertiary Care Inflammatory Bowel Disease Centers in the United States

Edward L. Barnes, Laura Raffals, Millie D. Long, Gaurav Syal, Maia Kayal, Ashwin Ananthakrishnan, Benjamin Cohen, Joel Pekow, Parakkal Deepak, Jean Frederic Colombel, Hans H. Herfarth, Robert S. Sandler

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Gaps exist in our understanding of the clinical course of pouch-related disorders. Methods: We evaluated baseline disease activity and longitudinal treatment patterns among patients with inflammatory conditions of the pouch. Results: Among 468 patients with an ileal pouch-anal anastomosis (IPAA), 94 (20%) had acute pouchitis, 96 (21%) had chronic pouchitis, and 192 (41%) had Crohn disease of the pouch. Following an IPAA, 38% of patients were treated with a biologic and 11% underwent inflammatory bowel disease- or bowel-related surgery. Conclusions: Treatment patterns after IPAA indicate that pouch-related disorders have a significant impact on individual patients and the healthcare system. Lay summary In a multicenter longitudinal cohort from 7 academic centers, a significant burden of inflammatory conditions of the pouch was demonstrated after restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalCrohn's and Colitis 360
Volume2
Issue number3
DOIs
StatePublished - Jul 1 2020

Keywords

  • Biologic therapy
  • Ileal pouch-anal anastomosis
  • Pouchitis

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