Discrimination of squamous cell carcinoma in situ from seborrheic keratosis by color analysis techniques requires information from scale, scale-crust and surrounding areas in dermoscopy images

N. M. Shakya, R. W. LeAnder, K. A. Hinton, S. M. Stricklin, R. K. Rader, J. Hagerty, W. V. Stoecker

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Scale-crust, also termed "keratin crust", appears as yellowish-to-tan scale on the skin's surface. It is caused by hyperkeratosis and parakeratosis in inflamed areas of squamous cell carcinoma in situ (SCCIS, Bowen's disease) and is a critical dermoscopy feature for detecting this skin cancer. In contrast, scale appears as a white-to-ivory detaching layer of the skin, without crust, and is most commonly seen in benign lesions such as seborrheic keratoses (SK). Distinguishing scale-crust from ordinary scale in digital dermoscopy images holds promise for early SCCIS detection and differentiation from SK. Reported here are image analysis techniques that best characterize scale-crust in SCCIS and scale in SK, thereby allowing accurate separation of these two dermoscopic features. Classification using a logistic regression operating on color features extracted from these digital dermoscopy structures can reliably separate SCCIS from SK.

Original languageEnglish
Pages (from-to)1165-1169
Number of pages5
JournalComputers in Biology and Medicine
Volume42
Issue number12
DOIs
StatePublished - Dec 1 2012

Keywords

  • Bowen's disease
  • Crust
  • Dermoscopy
  • Image processing
  • Scale
  • Seborrheic keratosis
  • Squamous cell carcinoma

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