Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO

Keyphrases

• Amide Isosteres 50%
• Amides 50%
• Bisamides 100%
• Cell Differentiation 50%
• Cell-based 100%
• Cell-based Assay 50%
• Differentiation Assay 50%
• Gli Transcription Factors 50%
• Hedgehog Antagonist 100%
• Hedgehog Inhibitor 50%
• Hedgehog Signaling Pathway 50%
• Heteroaryl 50%
• Imidazole 50%
• In Vivo Pharmacokinetics 50%
• Isosteric 100%
• Ligand-based 50%
• Optimization Strategy 50%
• P38 MAP Kinase 50%
• Physicochemical Properties 50%
• Potent Inhibitor 100%
• Reporter Cell Assay 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Carbon 11 33%
• Carboxamide 66%
• Hedgehog 100%
• Imidazole 33%
• Lead Compound 33%
• Pharmacokinetics 33%
• Phosphotransferase 33%
• Transcription Factors 33%