Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors

William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John J. Krais, Yifan Wang, Umeshkumar M. Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil JohnsonWayne Childers, Xiaojiang S. Chen, Richard T. Pomerantz

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Biochemistry, Genetics and Molecular Biology