@article{22268c243a744be5b469837288ab5a73,
title = "Discovery of a novel class of triazolones as Checkpoint Kinase inhibitors - Hit to lead exploration",
abstract = "Checkpoint Kinase-1 (Chk1, CHK1, CHEK1) is a Ser/Thr protein kinase that mediates cellular responses to DNA-damage. A novel class of Chk1 inhibitors, triazoloquinolones/triazolones (TZ's) was identified by high throughput screening. The optimization of these hits to provide a lead series is described.",
keywords = "CHK1, Checkpoint Kinase inhibitors, Triazolones",
author = "Vibha Oza and Susan Ashwell and Patrick Brassil and Jason Breed and Chun Deng and Jay Ezhuthachan and Heather Haye and Candice Horn and James Janetka and Paul Lyne and Nicholas Newcombe and Ludo Otterbien and Martin Pass and Jon Read and Sian Roswell and Mei Su and Dorin Toader and Dingwei Yu and Yan Yu and Anna Valentine and Peter Webborn and Ann White and Sonya Zabludoff and Xiaolan Zheng",
year = "2010",
month = sep,
day = "1",
doi = "10.1016/j.bmcl.2010.07.015",
language = "English",
volume = "20",
pages = "5133--5138",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
number = "17",
}