TY - JOUR
T1 - Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors
AU - Janetka, James W.
AU - Almeida, Lynsie
AU - Ashwell, Susan
AU - Brassil, Patrick J.
AU - Daly, Kevin
AU - Deng, Chun
AU - Gero, Thomas
AU - Glynn, Roberta E.
AU - Horn, Candice L.
AU - Ioannidis, Stephanos
AU - Lyne, Paul
AU - Newcombe, Nicholas J.
AU - Oza, Vibha B.
AU - Pass, Martin
AU - Springer, Stephanie K.
AU - Su, Mei
AU - Toader, Dorin
AU - Vasbinder, Melissa M.
AU - Yu, Dingwei
AU - Yu, Yan
AU - Zabludoff, Sonya D.
PY - 2008/7/15
Y1 - 2008/7/15
N2 - Checkpoint kinase-1 (Chk1, CHEK1) is a Ser/Thr protein kinase that mediates the cellular response to DNA-damage. A novel class of 2-ureido thiophene carboxamide urea (TCU) Chk1 inhibitors is described. Inhibitors in this chemotype were optimized for cellular potency and selectivity over Cdk1.
AB - Checkpoint kinase-1 (Chk1, CHEK1) is a Ser/Thr protein kinase that mediates the cellular response to DNA-damage. A novel class of 2-ureido thiophene carboxamide urea (TCU) Chk1 inhibitors is described. Inhibitors in this chemotype were optimized for cellular potency and selectivity over Cdk1.
UR - https://www.scopus.com/pages/publications/47149091445
U2 - 10.1016/j.bmcl.2008.05.016
DO - 10.1016/j.bmcl.2008.05.016
M3 - Article
C2 - 18547806
AN - SCOPUS:47149091445
SN - 0960-894X
VL - 18
SP - 4242
EP - 4248
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 14
ER -