Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing

Keyphrases

• Whole Exome Sequencing 100%
• Parkinson's Disease 100%
• Functional Prioritization 100%
• Drosophilidae 33%
• Neurodegeneration 16%
• Knockdown 16%
• Disease Case 16%
• Compound Heterozygous mutation 16%
• Large Cohort 16%
• Gain-of-function mutation 16%
• Genetic Disease 16%
• Caenorhabditis Elegans 16%
• Alpha-synuclein (α-syn) 16%
• RNA Interference 16%
• Idiopathic Parkinson's Disease 16%
• Disease Mechanisms 16%
• Susceptibility Variants 16%
• Disease-based 16%
• Disease Susceptibility 16%
• Disease Genes 16%
• Genetic Interaction 16%
• Experimental Strategies 16%
• Autosomal Recessive Inheritance 16%
• Human Genetics 16%
• Human Cell Culture 16%
• Genetic Etiology 16%
• Mitochondrial Dynamics 16%
• RNA Interference Screen 16%
• Neuronal Culture 16%
• Gene Candidates 16%
• VPS13C 16%
• ArsB 16%
• PTPRH 16%

Biochemistry, Genetics and Molecular Biology

• Exome Sequencing 100%
• Candidate Gene 100%
• RNA Interference 66%
• Genetics 33%
• Allele 33%
• Synuclein 33%
• Caenorhabditis Elegans 33%
• Autosomal Recessive Inheritance 33%
• Human Genetics 33%
• Gene Interaction 33%
• Human Cell Culture 33%
• Nerve Cell Culture 33%
• Gene Replication 33%
• Mitochondrial Dynamics 33%