Directly observing therapy: A new view of drug tolerance in tuberculosis

Jennifer A. Philips; Joel D. Ernst

doi:10.1016/j.cell.2011.02.041

Directly observing therapy: A new view of drug tolerance in tuberculosis

Jennifer A. Philips, Joel D. Ernst

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

Drug tolerance in bacteria is widely believed to be due to metabolic changes that accompany growth arrest. A study in this issue of Cell reveals a drug tolerance mechanism in replicating mycobacteria that is induced by residence in macrophages and depends on drug efflux.

Original language	English
Pages (from-to)	13-14
Number of pages	2
Journal	Cell
Volume	145
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2011.02.041
State	Published - Apr 1 2011

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10.1016/j.cell.2011.02.041

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title = "Directly observing therapy: A new view of drug tolerance in tuberculosis",

abstract = "Drug tolerance in bacteria is widely believed to be due to metabolic changes that accompany growth arrest. A study in this issue of Cell reveals a drug tolerance mechanism in replicating mycobacteria that is induced by residence in macrophages and depends on drug efflux.",

author = "Philips, {Jennifer A.} and Ernst, {Joel D.}",

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AU - Philips, Jennifer A.

AU - Ernst, Joel D.

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N2 - Drug tolerance in bacteria is widely believed to be due to metabolic changes that accompany growth arrest. A study in this issue of Cell reveals a drug tolerance mechanism in replicating mycobacteria that is induced by residence in macrophages and depends on drug efflux.

AB - Drug tolerance in bacteria is widely believed to be due to metabolic changes that accompany growth arrest. A study in this issue of Cell reveals a drug tolerance mechanism in replicating mycobacteria that is induced by residence in macrophages and depends on drug efflux.

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DO - 10.1016/j.cell.2011.02.041

M3 - Short survey

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SN - 0092-8674

VL - 145

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JO - Cell

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Directly observing therapy: A new view of drug tolerance in tuberculosis

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