TY - JOUR
T1 - Direct tests of enzymatic heme degradation by the malaria parasite Plasmodium falciparum
AU - Sigala, Paul A.
AU - Crowley, Jan R.
AU - Hsieh, Samantha
AU - Henderson, Jeffrey P.
AU - Goldberg, Daniel E.
PY - 2012/11/2
Y1 - 2012/11/2
N2 - Background: Malaria parasites detoxify copious amounts of heme during human infection, but enzyme involvement remains unclear. Results: Parasite-infected and uninfected erythrocytes contain indistinguishable low levels of heme catabolites, and a heme oxygenase-like parasite protein binds but does not degrade heme. Conclusion: P. falciparum parasites do not enzymatically degrade heme. Significance: This study comprehensively answers a long standing question regarding heme metabolism in this important parasite.
AB - Background: Malaria parasites detoxify copious amounts of heme during human infection, but enzyme involvement remains unclear. Results: Parasite-infected and uninfected erythrocytes contain indistinguishable low levels of heme catabolites, and a heme oxygenase-like parasite protein binds but does not degrade heme. Conclusion: P. falciparum parasites do not enzymatically degrade heme. Significance: This study comprehensively answers a long standing question regarding heme metabolism in this important parasite.
UR - http://www.scopus.com/inward/record.url?scp=84868310578&partnerID=8YFLogxK
U2 - 10.1074/jbc.M112.414078
DO - 10.1074/jbc.M112.414078
M3 - Article
C2 - 22992734
AN - SCOPUS:84868310578
SN - 0021-9258
VL - 287
SP - 37793
EP - 37807
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 45
ER -