Direct tests of enzymatic heme degradation by the malaria parasite Plasmodium falciparum

Paul A. Sigala, Jan R. Crowley, Samantha Hsieh, Jeffrey P. Henderson, Daniel E. Goldberg

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Background: Malaria parasites detoxify copious amounts of heme during human infection, but enzyme involvement remains unclear. Results: Parasite-infected and uninfected erythrocytes contain indistinguishable low levels of heme catabolites, and a heme oxygenase-like parasite protein binds but does not degrade heme. Conclusion: P. falciparum parasites do not enzymatically degrade heme. Significance: This study comprehensively answers a long standing question regarding heme metabolism in this important parasite.

Original languageEnglish
Pages (from-to)37793-37807
Number of pages15
JournalJournal of Biological Chemistry
Volume287
Issue number45
DOIs
StatePublished - Nov 2 2012

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