Direct chromosome preparations from chorionic villi: A method for obtaining extended chromosomes and recognizing mosaicism confined to the placenta

S. W. Cheung, J. P. Crane, M. Kyine, M. Y. Cui

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations

    Abstract

    A modified technique is described for obtaining extended metaphase chromosomes (600 bands) from direct preparations of chorionic villi, allowing rapid detection of subtle structural aberrations with minimal risk of maternal-cell contamination. Analysis of multiple individually processed villus fragments may be helpful in recognizing mosaicism confined to chorionic villi.

    Original languageEnglish
    Pages (from-to)118-120
    Number of pages3
    JournalCytogenetic and Genome Research
    Volume45
    Issue number2
    DOIs
    StatePublished - 1987

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